The Science Behind Hormizon NAD+

Clinical Evidence

The science is real.
So are the results.

Every ingredient in Hormizon NAD+ Men's Complex was chosen for one reason: published research showing it works, at doses that actually move the needle, for the exact problem you came here to solve.

14Active Ingredients
37+Clinical Studies Referenced
9xBetter Absorption vs Standard Capsules
60Day Money-Back Guarantee

Our Approach

Not one ingredient.
A complete system.

Most supplements do one thing. They throw L-Arginine at the problem and hope for the best. That is putting gas in a car with a dead battery.

Hormizon restores the battery first. Then floods blood flow. Then removes the stress hormone that clamps everything shut. Three steps in order. Skip step one and nothing else works.

1

Recharge the battery

NAD+ is the cellular fuel your body runs on. After 30 it drops. Without it, nothing downstream works.

2

Flood blood flow

Once the battery is back, L-Arginine and L-Citrulline give your body what it needs to produce nitric oxide.

3

Remove the roadblocks

Stress hormones clamp blood vessels shut. KSM-66, CoQ10 and the rest protect the signal so it gets through.

Group 1 of 3: Cellular Energy

Ingredients 01 to 04 - These recharge the battery that everything else runs on

01
Liposomal NAD+
Nicotinamide Adenine Dinucleotide
The master molecule - delivered 9x better
The cellular battery. After 30, it starts dying. Recharge it and everything comes back online.
9x better absorption than standard capsules
What it does:
NAD+ is the fuel your cells use to produce energy and run every biological process that keeps you functioning. After 30, your levels drop roughly 50% per decade. When NAD+ is gone, the enzyme chain your body uses to produce nitric oxide shuts down. Standard capsules get destroyed by stomach acid before reaching your cells. The liposomal coating in Hormizon wraps NAD+ in a fat-soluble shell that bypasses acid and delivers 9x more into your bloodstream.
  • -Powers the enzyme chain your body uses to produce nitric oxide
  • -Restores energy in the blood vessel cells that control blood flow
  • -Supports testosterone production in the cells that make it
  • -Reduces inflammation - confirmed across a meta-analysis of 29 studies
Clinical Mechanism - Nitric Oxide Production
MIT confirmed: restoring NAD+ reactivates the enzyme your body uses to produce nitric oxide in blood vessels.
NAD+ activates a regulatory enzyme (SIRT1) that directly switches on the nitric oxide production enzyme (eNOS) in blood vessel cells. When NAD+ is depleted, the whole chain shuts down from the top. No NAD+ means no switch, no engine, no blood flow signal.
MIT News, 2018 - View Study
Clinical Study - Vascular Function
NMN supplementation significantly improved endothelial function and restored nitric oxide production in aged blood vessels.
NMN (an NAD+ precursor) rescued the angiogenic capacity of aged endothelial cells - the cells lining your blood vessels. Harvard study confirmed NMN restores the ability of aged endothelial cells to form new blood vessels and convert glucose into energy.
PubMed 31144244, 2019 - View Study
Meta-Analysis - 29 Studies
NAD+ precursors led to significant reductions in blood pressure and inflammation markers across 29 human studies.
A meta-analysis reviewing 29 clinical studies confirmed that NAD+ precursor supplementation produces measurable reductions in blood pressure and systemic inflammation. Oral NADH also associated with improvements in quality of life and reductions in anxiety.
EverydayHealth Meta-Analysis - View Study
02
CoQ10
Coenzyme Q10 - Ubiquinone
Powers cells alongside NAD+
NAD+ and CoQ10 work together inside your cells. Both required for full energy restoration.
Meta-analysis: 877 men, significant testosterone increase
What it does:
CoQ10 is an essential cofactor in the mitochondrial energy chain, working directly alongside NAD+. When both are present, cellular energy production compounds. For testosterone specifically, CoQ10 reduces oxidative stress in the cells that produce testosterone (Leydig cells). A meta-analysis of 877 men confirmed CoQ10 significantly increased testosterone versus placebo.
  • -Works with NAD+ inside the mitochondria to restore cellular energy
  • -Reduces oxidative stress in testosterone-producing cells
  • -Meta-analysis of 877 men: significant testosterone increase vs placebo
  • -Strong antioxidant protecting the nitric oxide signal from free radical destruction
Meta-Analysis - Testosterone (877 Men)
CoQ10 supplementation significantly increased testosterone levels - confirmed in a systematic review and meta-analysis of 877 men.
A comprehensive meta-analysis in Frontiers in Pharmacology confirmed CoQ10 improves testicular function by reducing oxidative stress in Leydig cells (the cells that make testosterone). The effect size was statistically significant at p less than 0.00001.
Frontiers in Pharmacology, 2024 - View Study
03
Trans-Resveratrol
Stilbenoid polyphenol
Protects the blood flow signal
Free radicals destroy nitric oxide before it arrives. Resveratrol neutralizes them so the signal actually gets through.
Published research: restores erectile function via SIRT1
What it does:
Free radicals in your bloodstream destroy nitric oxide before it reaches your blood vessels. This means your body produces the signal but it never arrives. Resveratrol neutralizes those free radicals and also activates the same enzyme chain NAD+ powers - via a separate pathway. Combined, they compound the effect. It also works synergistically with ED medications, making them more effective rather than interfering.
  • -Protects nitric oxide from free radical destruction after it is produced
  • -Activates the nitric oxide enzyme chain via a separate pathway from NAD+
  • -Restores erectile function in published research by preserving the production chain
  • -Works synergistically with ED medications - compounds the effect
Published Research - Erectile Function
Resveratrol restored erectile function in published research by preserving the nitric oxide production chain and antioxidant defense.
Multiple published studies confirm resveratrol restores erectile function by protecting and activating the SIRT1-eNOS nitric oxide production chain. It also preserves endothelium-dependent relaxation directly in corpus cavernosum tissue - the tissue that enables erections.
PMC Research, 2014 - View Study
Synergy Study - ED Medication
Resveratrol combined with ED medication synergistically enhanced the nitric oxide pathway - greater effect than either alone.
For men currently using Cialis or Viagra: resveratrol compounds the effect rather than interfering. This makes Hormizon compatible with current medication use while also providing standalone benefit for men not using medication.
PubMed 21269399, 2011 - View Study
04
L-Carnitine
Amino acid derivative
Converts fat to clean cellular energy
In a head-to-head study, L-Carnitine outperformed testosterone therapy itself for improving erectile function.
Outperformed testosterone therapy in RCT
What it does:
L-Carnitine carries fat into your cells to be burned as energy, working with CoQ10 and NAD+ to keep the cellular engine running at full capacity. A landmark randomized controlled trial compared L-Carnitine directly against testosterone replacement therapy. L-Carnitine outperformed testosterone therapy on multiple primary endpoints including erection quality and morning erections.
  • -Shuttles fat into cells to be converted to energy - works with NAD+ and CoQ10
  • -Outperformed testosterone therapy for erectile function in head-to-head RCT
  • -Improves nocturnal penile tumescence (morning erections)
  • -Upregulates androgen receptor density within 3 weeks at clinical dose
Head-to-Head RCT - vs Testosterone Therapy
L-Carnitine produced significantly greater improvements in erectile function and morning erections than testosterone therapy itself.
A randomized controlled trial compared L-Carnitine directly to testosterone replacement therapy in men with sexual dysfunction. L-Carnitine outperformed testosterone on erectile function scores, nocturnal erections, and overall sexual satisfaction.
PubMed 15072869, 2004 - View Study

Group 2 of 3: Blood Flow and Hormones

Ingredients 05 to 11 - These produce nitric oxide, optimize testosterone, and remove roadblocks

05
L-Arginine
Amino acid - direct nitric oxide precursor
High clinical dose - the raw material for nitric oxide
The amino acid your body converts directly into nitric oxide. Once the battery is recharged, this is the raw material the engine needs.
Double-blind placebo-controlled trial in men with ED
What it does:
L-Arginine is the amino acid your body uses to make nitric oxide - the molecule that relaxes blood vessel walls and drives blood flow. High-dose oral L-Arginine has been confirmed in double-blind placebo-controlled studies to improve erectile function in men with vascular ED. Most supplements under-dose this ingredient. Hormizon uses the clinical threshold.
  • -Direct raw material for nitric oxide production
  • -High-dose clinical threshold used in vasculogenic ED trials
  • -Confirmed in double-blind placebo-controlled studies in men with ED
  • -Synergy: NAD+ restarts the engine. Resveratrol amplifies it. L-Arginine feeds it.
Clinical Trial - Vasculogenic ED in Men
High-dose L-Arginine significantly improved erectile function scores in men with vasculogenic erectile dysfunction in an RCT.
A double-blind placebo-controlled trial confirmed high-dose oral L-Arginine improves erectile function in men with vascular ED. The 2023 meta-analysis and systematic review in Frontiers in Endocrinology further confirmed the benefit across multiple trials.
PubMed 10233492 - View Study
06
L-Citrulline
Amino acid - nitric oxide recycler
Keeps nitric oxide flowing for hours, not minutes
L-Arginine gives you the first hit. L-Citrulline keeps it going. A steady wave, not a spike.
Improved erection hardness in men with mild ED
What it does:
Your body recycles L-Citrulline back into L-Arginine in the kidneys, sustaining nitric oxide production for hours instead of getting a short spike. L-Citrulline actually raises blood arginine levels more effectively and for longer than L-Arginine alone because it bypasses liver metabolism. A clinical trial confirmed improved erection hardness in men with mild ED.
  • -Recycled back into L-Arginine, sustaining nitric oxide production over hours
  • -Raises blood arginine more effectively than standalone L-Arginine
  • -Clinical trial confirmed improved erection hardness in men with mild ED
  • -Combined with L-Arginine: steady wave strong enough to work even under stress
Randomized Double-Blind Trial - ED in Men
Oral L-Citrulline improved erection hardness scores in men with mild erectile dysfunction versus placebo.
A randomized, double-blind, placebo-controlled clinical trial confirmed L-Citrulline supplementation significantly improved erection hardness scale scores in men with mild ED. Men receiving L-Citrulline reported higher satisfaction rates with their sexual performance.
PubMed 21195829, 2011 - View Study
07
KSM-66 Ashwagandha
Withania somnifera root extract
The most clinically studied ashwagandha form
Lowers the stress hormone that clamps blood vessels shut right when you need them open.
27.9% cortisol reduction measured in the bloodstream
What it does:
When you are stressed, your body floods with cortisol. Cortisol is a vasoconstrictor - it clamps blood vessels shut. One bad night becomes a pattern. KSM-66 is backed by over 22 gold-standard human trials. It does not sedate you. It regulates the system that decides how much cortisol to produce in the first place. The cortisol reduction is measured directly in the bloodstream via blood test, not just how you feel.
  • -Reduces cortisol measured in the bloodstream - not just self-reported
  • -Significant improvements in testosterone and sexual well-being in men
  • -Improves sleep onset, total sleep time, and sleep efficiency
  • -Safe at clinical dose for up to 12 months per published safety studies
Clinical Trial - Cortisol Reduction, 60 Days
27.9% reduction in bloodstream cortisol in a 60-day randomized double-blind placebo-controlled trial in adults with chronic stress.
KSM-66 at 600mg/day produced a 27.9% drop in serum cortisol alongside significant improvements on all three standardized stress scales (PSS, DASS, GHQ-28) in a randomized double-blind placebo-controlled trial of 64 adults.
Chandrasekhar et al. 2012 - View Study
Clinical Trial - Testosterone and Sexual Function
KSM-66 significantly improved testosterone levels, vitality, and sexual well-being in men in a randomized placebo-controlled trial.
Published in 2022 in Wiley. KSM-66 supplementation improved testosterone, DHEA-S, and overall vitality scores versus placebo in men. A separate 2019 trial in aging overweight males confirmed hormonal and vitality improvements.
PubMed 35873404, 2022 - View Study
08
Zinc Bisglycinate
Highly bioavailable zinc form
Supports testosterone production
Your body cannot produce testosterone without it. Most men over 40 are zinc-deficient without knowing it.
Direct correlation between zinc and testosterone confirmed
What it does:
Zinc is a cofactor required at multiple steps in the testosterone biosynthesis pathway. When zinc is low, testosterone follows. A systematic review of 14 studies confirmed a direct positive correlation between serum zinc and testosterone. Bisglycinate is the most absorbable form of zinc - far superior to zinc oxide which is what most supplements use to cut costs.
  • -Required cofactor for multiple steps in testosterone production
  • -Systematic review confirmed direct correlation with testosterone across 14 studies
  • -Improved sexual performance and erectile function in 2023 PMC study
  • -Bisglycinate form: maximum absorption vs cheap zinc oxide used by competitors
Systematic Review - Zinc and Testosterone
Significant positive correlation between serum zinc and testosterone confirmed across a systematic review - zinc deficiency directly suppresses testosterone output.
A 2022 systematic review and meta-analysis confirmed the direct relationship between zinc status and testosterone levels. Zinc is a cofactor for multiple steroidogenic enzymes. Deficiency reduces the activity of the entire testosterone production pathway.
PubMed 36577241, 2022 - View Study
09
Stinging Nettle Root
Urtica dioica extract
Frees trapped testosterone
Your labs can say "normal testosterone" while almost none of it is actually available to your cells. Nettle Root fixes that.
Binds SHBG - increases free, usable testosterone
What it does:
A protein called SHBG (sex hormone binding globulin) grabs onto testosterone in your blood and locks it up. You can have normal total testosterone on a blood test while free testosterone is suppressed because SHBG is trapping it. Nettle Root binds directly to SHBG instead, displacing testosterone and increasing the fraction of free, active testosterone your cells can actually use.
  • -Binds to SHBG, displacing trapped testosterone and freeing it for use
  • -Increases free testosterone without changing total testosterone
  • -Also inhibits aromatase - prevents testosterone from converting to estrogen
  • -Explains why labs can look "normal" while performance is still poor
Mechanism Research - Free Testosterone
Nettle Root extract binds to SHBG, displacing testosterone and increasing the fraction of free, bioavailable testosterone - without affecting total testosterone levels.
This is why men say "all my labs are normal but nothing works." Total testosterone measures bound and free combined. Only free testosterone can be used by cells. Nettle Root increases the active fraction without needing to produce more testosterone.
ScienceDirect - SHBG Binding Review
10
Maca Root Extract
Lepidium meyenii
Restores sexual desire
Blood flow is the physical side. Desire is the other side. Maca works on the side everything else ignores.
Double-blind RCT in men with mild ED
What it does:
Blood flow and erections are the physical mechanism. Desire and sexual motivation are the other half. Maca Root works through a completely separate pathway - not hormonal and not nitric oxide - that directly supports sexual motivation and satisfaction. A double-blind study showed it significantly improved sexual well-being in men with mild ED. Its effects are independent of testosterone, confirmed in the research.
  • -Supports sexual desire through a pathway separate from blood flow and testosterone
  • -Double-blind RCT confirmed improved sexual well-being in men with mild ED
  • -Systematic review: consistent evidence for improving sexual desire across multiple trials
  • -Effects independent of hormonal changes - confirmed in research
Double-Blind RCT - Sexual Well-Being in Men
Maca extract significantly improved subjective well-being and sexual performance in men with mild erectile dysfunction versus placebo.
A randomized, double-blind, placebo-controlled trial confirmed maca's effect on sexual performance and overall well-being in men with mild ED. Effect was independent of hormonal changes, confirming a distinct non-hormonal mechanism separate from everything else in the formula.
PubMed 19260845, 2009 - View Study
11
Turmeric Extract
Curcuma longa (95% curcuminoids)
Reduces vascular inflammation
Chronic inflammation silently damages blood vessel walls over years. Turmeric shuts down the signal at the source.
Published in Wiley Andrologia - ED-specific research
What it does:
Chronic low-level inflammation is one of the main reasons erections become unreliable with age. It damages blood vessel walls from the inside over years. Turmeric's active compound (curcumin) inhibits NF-KB - the master switch of inflammatory cascades. Multiple published studies confirm it directly improves erectile signaling and protects the nitric oxide signal after it is produced.
  • -Inhibits NF-KB: the master switch of inflammatory cascades that damage blood vessels
  • -Directly improved erectile signaling in vascular ED research models
  • -Published in Wiley Andrologia 2023: confirmed curcumin protects erectile tissue
  • -Protects nitric oxide from free radical destruction after production
Published Research - Andrologia, 2023
Curcumin attenuated erectile dysfunction by protecting against cell damage in erectile tissue - published in Wiley Andrologia.
Curcumin's anti-inflammatory and antioxidant mechanisms directly target the endothelial dysfunction pathway underlying vascular ED. Multiple studies confirm benefit in diabetic and vascular ED models. Effect confirmed across standard and enhanced curcumin formulations.
Wiley Andrologia, 2023 - View Study

Group 3 of 3: Prostate Health

Ingredients 12 to 14 - Prostate issues are a hidden cause of ED many men never address

12
Saw Palmetto Berry Extract
Serenoa repens
Prostate support without sexual side effects
Prostate swelling causes nighttime trips, disrupts sleep, and contributes to ED. Saw Palmetto addresses it without the side effects of the pharmaceutical version.
82-man RCT: improved sexual function in men with BPH
What it does:
Prostate inflammation and swelling are significantly more common in men with ED than most realize. An 82-man clinical trial showed Saw Palmetto significantly improved both prostate symptoms and sexual function in 8 weeks. Unlike finasteride (the pharmaceutical alternative), Saw Palmetto does not cause sexual side effects. In fact the pharmaceutical version worsens ED as a side effect.
  • -Reduces prostate swelling without the sexual dysfunction side effects of finasteride
  • -82-man RCT: improved sexual function in men with prostate issues after 8 weeks
  • -Reduces nighttime bathroom trips - better sleep means more testosterone production
  • -Synergistic with Beta-Sitosterol: dual prostate protection mechanism
Clinical Trial - BPH and Sexual Function
Saw Palmetto 320mg significantly improved prostate symptoms AND sexual dysfunction in men over 8 weeks - without the sexual side effects of pharmaceutical alternatives.
Men with prostate issues face a compounding problem: prostate symptoms disrupt sleep and contribute to ED, while the primary pharmaceutical treatment (finasteride) actually worsens ED as a side effect. Saw Palmetto addresses the prostate problem without that trade-off.
PubMed 22522969, 2012 - View Study
13
Beta-Sitosterol
Plant-derived phytosterol
Cochrane-reviewed prostate compound
The most evidence-backed natural compound for prostate health in the published literature.
Cochrane systematic review: gold-standard evidence confirmed
What it does:
Beta-Sitosterol is confirmed by a Cochrane systematic review - the highest standard of clinical evidence - to significantly improve urinary symptoms and flow in men with prostate issues. Its anti-prostate effect is comparable to finasteride in head-to-head analysis, without the sexual dysfunction side effects. Combined with Saw Palmetto, the effect compounds through two separate mechanisms.
  • -Cochrane review confirmed: significantly improves urinary symptoms and peak flow rate
  • -Comparable efficacy to finasteride without the sexual dysfunction side effects
  • -Synergistic with Saw Palmetto: two separate prostate protection mechanisms
  • -Well-tolerated in long-term use across multiple randomized controlled trials
Cochrane Systematic Review - BPH
Beta-Sitosterol significantly improved urinary symptom scores and peak urine flow in men with prostate enlargement - confirmed by Cochrane systematic review.
The Cochrane systematic review is considered the highest standard of clinical evidence synthesis. The review of randomized trials on Beta-Sitosterol for prostate issues confirmed significant, clinically meaningful improvement in international prostate symptom scores and urinary flow rates.
Cochrane Review - View Study
14
Lycopene
Carotenoid antioxidant
Concentrates in prostate tissue - protects from the inside
The most powerful antioxidant in prostate tissue. At 15mg per day it was shown to slow prostate enlargement progression.
Inhibited BPH progression in clinical trial at 15mg/day
What it does:
Lycopene naturally accumulates in prostate tissue more than anywhere else in the body. Its antioxidant power is 2x that of beta-carotene and 10x that of Vitamin E. A published clinical trial showed 15mg per day inhibited BPH disease progression. Combined with Saw Palmetto and Beta-Sitosterol, it forms a three-compound prostate protection stack covering antioxidant, anti-inflammatory, and hormonal pathways simultaneously.
  • -Concentrates naturally in prostate tissue - targeted by your own biology
  • -Antioxidant power 10x stronger than Vitamin E at the same dose
  • -15mg/day inhibited prostate enlargement progression in published clinical trial
  • -Three-compound stack with Saw Palmetto and Beta-Sitosterol for full prostate coverage
Clinical Trial - Prostate Enlargement
Lycopene at 15mg per day inhibited BPH disease progression in a published clinical trial - the first carotenoid shown to slow prostate enlargement.
Lycopene accumulates in higher concentrations in the prostate than any other tissue. Its anti-inflammatory action in prostate tissue works alongside Saw Palmetto's 5-alpha-reductase inhibition and Beta-Sitosterol's urinary flow improvement to form comprehensive prostate coverage.
Journal of Nutrition - View Study

Common Questions

Real questions.
Real answers.

These are the questions we would want answered before buying a supplement. Here they are in plain English, not marketing language.

I tried L-Arginine before and it did nothing. Why would this be different?
Because your cells did not have the energy to use it. L-Arginine needs a specific enzyme to convert it into nitric oxide. That enzyme needs NAD+ to run. After 30, NAD+ drops and the enzyme shuts down. You were pouring raw material into a machine that was turned off. Hormizon restores the machine first. Then L-Arginine has something to work with.
My doctor said my testosterone is normal. Why am I still having problems?
Because total testosterone on a blood test is not the same as testosterone your cells can use. A protein called SHBG grabs onto testosterone in your blood and locks it up. Your labs can look fine while most of your testosterone is unavailable to your body. Nettle Root in Hormizon frees that locked-up testosterone so your body can actually use what it is already making.
How long until I notice something?
Most men notice better energy and sleep in weeks 1 to 2. Blood flow and bedroom improvements typically show up by weeks 3 to 4. The full effect builds over 60 to 90 days of consistent daily use. That is why the 60-day guarantee exists. One bottle is the minimum meaningful trial period.
Can I take this if I am on Cialis or Viagra?
Talk to your doctor before combining with prescription medication. That said, Hormizon works at a completely different level. Those medications preserve whatever nitric oxide your body is already producing. Hormizon restores your body's ability to produce it in the first place. Resveratrol in the formula has been shown in published research to actually enhance the effect of ED medications rather than interfering.
Is this safe to take every day long-term?
Yes. All 14 ingredients are natural with no stimulants or artificial additives. KSM-66 Ashwagandha has been studied in a 12-month safety trial showing no adverse effects on liver, kidney or thyroid. The formula is third-party tested and manufactured in a GMP-certified facility in the USA. If you have a medical condition or take prescription medications, consult your doctor before starting.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before use if you have a medical condition or take prescription medications.